Activities

On December 7th, 2006, EFSPI hold a Scientific One-day Meeting on Adaptive Randomisation – Today and Tomorrow

Opinion leaders from industry, academia and regulatory shared their views on Adaptive Randomisation, in particular focusing on covariate balancing, via presentations and a panel discussion. A number of case studies and papers have also been presented in the afternoon session.
Members of the audience were able to question the opinion leaders during panel discussion. This controversial subject generated an interesting debate.

Slides presented during the meeting are available below:

Morning: Adaptive Randomisation – A Personal and Collective Perspective
• Why I hate Minimisation Stephen Senn (University of Glasgow) 
• Minimization, permuted blocks and simple randomization: Marc Buyse (IDDI)
• Dynamic allocation : How to stratify if you must: Kit Roes (Organon and EFSPI)
• Regulatory perspective: P. Volkers (Paul-Ehrlich-Institute)
  
  
• Discussion : Andy Grieve (Pfizer)
  
  Afternoon session 1
• Use of the Minimization Technique at the EORTC: History and Experience: C.Coens (EORTC)
• Minimisation – Reducing Predictability whilst Retaining Balance within Centres: S. Brown (CTRU, University of Leeds)
• Case Studies Using Dynamic Randomisation Techniques other than Minimisation: D. McEntegart (ClinPhone)
  
  Afternoon session 2
• Use of Simulation to Compare the Performance of Minimisation with Conventional Stratified Randomisation: R. Toorawa (Covance)
• Inference in Covariate-Adaptive Allocation: E. Valdés Márquez (MPS, University of Reading)
• A European Project for the Development and Deployment of a Validated Randomisation System: E. van der Donk (NKI)